High dose vitamin C may well be an important treatment for some acute conditions, but by far the most important and easily corrected nutritional deficiency is that most people have only a fraction of the 50 ng/mL circulating 25-hydroxyvitamin D their immune system needs to function properly.
The best approach is to supplement vitamin D3 in sufficient quantities to attain this. This takes several months at healthy average daily intakes such as 125 micrograms (5000 IU) for 70 kg (154 lb) body weight without obesity. The above page starts with recommendations from New Jersey based Professor of Medicine Sunil Wimalawansa on how much vitamin D3 to supplement, on average, per day, in order to safely attain at least the 50 ng/mL circulating 25-hydroxyvitamin D the immune system needs, without the need for blood tests or medical monitoring.
Bolus (single, large AKA "loading") vitamin D3 is the most common approach to boosting low levels, such as 15 ng/mL or less to 50 ng/mL or more in clinical emergencies.
There is an urgent, hour-to-hour, need to raise circulating 25-hydroxyvitamin D to 50 ng/mL or more in all cases of sepsis, Kawasaki disease, MIS-C, severe or potentially severe COVID-19, influenza, ARDS etc. In cancer, the urgency is somewhat less, but it is still vital to enable the immune system to function properly, including by reducing the risk of self-destructive, overly inflammatory, immune responses.
The ESPEN (European Society for Clinical Nutrition and Metabolism) guideline on clinical nutrition in the intensive care unit, Singer et al. 2014: Clinical Nutrition https://www.sciencedirect.com/science/article/pii/ S0261561418324324 states that "a single high dose (500,000 IU) can be administered in the first week and seems safe in patients with deficiency." Most people are deficient with respect to 50 ng/mL circulating 25-hydroxyvitamin D.
A smaller amount, according to body weight, would be appropriate for infants and children.
This vitamin D3 takes a few days to be hydroxylated, mainly in the liver, to the circulating 25-hydroxyvitamin D the immune system needs. (Only about 1/4 of ingested or UV-B -> skin produced vitamin D3 becomes this circulating 25-hydroxyvitamin D.)
The best approach, as recommended by Prof. Wimalawansa, is a single oral dose of about 1 mg of calcifediol (for 70 kg body weight). Calcifediol *is* 25-hydroxyvitamin D. This is easily absorbed and goes straight into circulation in the bloodstream. This will raise the 25(OH)D level safely over 50 ng/mL in about 4 hours. https://vitamindstopscovid.info/00-evi/#4.7.
My top 3 are D3, magnesium and Lugols iodine. 95% of us are iodine deficient, (Dr David Brownstein). Both iodine and D3 are needed for our immune system.
Very good. Dr Coimbra (Coimbra Protocol) uses high dose D3 to alleviate symptoms of MS, autism, Parkinsons, Alzheimer's, etc. Most of our cells in our body have vitamin D receptors, including our brain. Since low dose D3 takes 3 months to increase in our body he does a one time dose of 600,000iu D3 for patients that have to go in the hospital since it bumps up faster. He has now incorporated Dr Christopher Exley (Substack) protocol of chelating aluminum from our body with mineral water high in silica. For some strange reason we have a high toxicity of aluminum in our brains.
Dr Coimbra and the German doctors who treat patients with his protocol: https://www.mdpi.com/2072-6643/14/8/1575 propose that the high vitamin D3 intake suppressed autoimmune inflammatory disorders by overcoming a very vaguely described "vitamin D resistance", such as some kind of problem absorbing vitamin D3. This makes no sense, since the levels of 25-hydroxyvitamin D they reach are very high, and are typically, at least for treating multiple sclerosis, borderline or actually toxic, unless special precautions are taken to minimise calcium intake. The protocol takes this level way out of observed range of natural levels - up to 70 ng/mL or so - into the hundreds of ng/mL.
They don't seem to be aware that the inflammatory disorders they are tackling are caused in large part by our lack of helminths. A substack comment is not the place to explain this properly, so please see: https://vitamindstopscovid.info/06-adv/ and in particular the end of this section https://vitamindstopscovid.info/06-adv/#cc.
I need to update this, because when I wrote it I did not have a hypothesis as to why the Coimbra Protocol's very high 25-hydroxyvitamin D levels suppressed the excessive, inflammatory (self destructive, indiscriminate, cell destruction).
I now have a hypothesis. I should write to Dr Coimbra and the German doctors about this. See the end of my "(2 of 3)" comment at: https://www.aporiamagazine.com/p/beauty-as-a-biological-construct. I need to develop this some more. Briefly, the very high level of circulating 25-hydroxyvitamin D, raises, by diffusion, the level of 25-hydroxyvitamin D in the cytosol (the fluid inside) all cells, including the cytosol of Th1 regulatory lymphocytes.
Chauss et al. did beautiful work elucidating the intracrine (they called it "autocrine") signaling system in Th1 lymphocytes by which an initially inflammatory state (their "startup program") of these cells (putting out more of a pro-inflammatory cytokine than of an anti-inflammatory cytokine) is normally reversed when a condition (a high level of a complement protein) is detected. This activates the 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol) intracrine signaling system inside the cell, which creates intracellular calcitriol which then binds to the "vitamin D" receptor molecule (really the calcitriol receptor molecule) which the activated intracrine signaling system also creates, or at least raises the level of, in the cytosol. The resulting bound complex binds, in the nucleus, with retinol X and the triple complex alters gene transcription in cell-type specific ways, up- and down-regulating the transcription of dozens to hundred of genes. Which genes are up- and down-regulated when calcitriol binds to the VDR molecule varies greatly from one cell type to the next. Likewise, for those cells which have such an intracrine signaling system, the condition which activates also varies greatly from one cell type to the next. (These systems are not related to hormonal signalling.)
In the case of Th1 lymphocytes, the gene expression changes alter protein synthesis in ways which alter the behavior of the cell so it switches to an anti-inflammatory shutdown program: producing less of the pro-inflammatory cytokine and more of the anti-inflammatory cytokine.
My explanatory hypothesis for the Coimbra (and McCullough and Batchelor) Protocol(s) is that the very high level of 25-hydroxyvitamin D in the cell causes a significant amount of 25-hydroxyvitamin D binding to a presumed background level of "vitamin D" receptor (VDR) molecules at all times. This is because although the VDR molecule has a high binding affinity with calcitriol, it has also has an affinity to bind with 25-hydroxyvitamin D, albeit a much lower affinity. I propose that the very high level of 25-hydroxyvitamin D causes sufficient binding to VDR molecules that the anti-inflammatory pattern of gene expression is always enabled.
So, in people with very high (150 ng/mL or more) 25-hydroxyvitamin D levels, as the Coimbra Protocol often achieves, I propose that their Th1 lymphocytes can never be in their startup program of being pro-inflammatory, even when these cells first begin their existence - or at least 25-hydroxyvitamin D binding to the VDR molecule this happens to some extent which is sufficient to suppress the worst of the excessive inflammation which causes these auto-immune inflammatory conditions.
Thx. I found it amazing that Dr Bruce Hollis did an FDA approved study back in the 90’s showing 4,000iu (max allowed by FDA) D3 daily shrank prostate tumors during a 3 month period. He also noted the has the ability to convert 25 hydroxy to 1,25 dihydroxy.
Robin, yes Exley's book is excellent as are all his papers. Some rare actual science. For serious readers or researchers it needed an index so I compiled a detailed one. It's in PDF format. It was posted on his substack but not updated. Let me know if you are interested - then we will work out a way to get it to you or anyone interested.
I have a question about the vit D family. When we see an association between low Vitamin D and illness does that mean that low Vit D CAUSED the illness or is the reverse true: does the illness cause a decrease in Vit D like compounds - is this part of a necessary biochemical dance?
Does supplementation during this illness cure the disease? Dr Tom Cowan did a review of about 40 papers on Vit D indicating we might be victims of the association = causation trap that the human brain is designed to fall into! This might be on BitChute.
25-hydroxyvitamin D (as tested in "vitamin D" blood tests) is needed to supply many types of immune cell which need it for intracrine (inside each cell) and paracrine (to nearby cells) signaling. Please see my tutorial on these signaling systems at: https://vitamindstopscovid.info/00-evi/#02-compounds. All medical professionals, immunologists etc. and anyone seriously interested in health needs to understand these, but few have ever heard of them.
There is limited evidence of 25-hydroxyvitamin D levels dropping with severe illness. This is easily misinterpreted as being a bigger effect than what actually happens, as far as I can tell. I don't recall the research, but there was one trial in which a strong inflammatory response was induced, I think with bacterial toxins, and a modest drop in 25-hydroxyvitamin D was measured.
This does not alter the numerous observations which indicate that 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D is needed for full immune system function, and that rapidly boosting this in serious infections, including sepsis, helps the patient recover.
Please spend a couple of hours reading https://vitamindstopscovid.info/00-evi/ and looking at some or all of the research I cite. Then you will have a good understanding of these signaling systems and why 50 ng/mL or more circulating 25-hydroxyvitamin D is so important for health. You will then see that this is not related to hormonal signaling and that it is important to refer to the three compound clearly at all times - they are not all "vitamin D":
Yes, but strictly High in silicic acid Si(OH)4 not silica SiO2. I am clarifying this point because many people think they can buy a silica product and recover from Dementia and the other 37 diseases linked to/caused by aluminum.
I just follow Dr Christopher Exley (Substack) protocol of using mineral water with over 30mg/l of silica. I know others are also adding silica to water but I am not sure of what type.
First there is no such thing as Covid 19. That was all made up. I recommend 'Can You Catch A Cold?' and 'Virus Mania'
Also be careful not to overdose on D. More is NOT better. This sounds dramatic but worth knowing especially if you have pets that might chomp on tasty morsels of D-Con.
Vitamin D or cholecalciferol is the main ingredient in rat poison.
Anyone who is tempted to believe what DDR Dave wrote about vitamin D3 cholecalciferol and 25-hydroxyvitamin D calcifediol should read the research cited and discussed at: https://vitamindstopscovid.info/00-evi/.
If we ate the same quantity of vitamin D3, as a ratio of body weight, as rats, we too would die a horrible death. This doesn't alter the fact that in order to attain the 50 ng/mL or more circulating 25-hydroxyvitamin D our immune systems need to function properly, that we need to ingest ca. 125 micrograms of vitamin D3 a day, on average (for 70 kg body weight without obesity) OR generate it ourselves with large amounts of UV-B exposure of ideally white skin, which is impractical and always damages DNA and so raises the risk of skin cancer.
Of course viruses exist, as does the now large variety of SARS-CoV-2 viruses, which infect, harm and sometimes kill people. Do you think all this is entirely made up: https://www.nature.com/articles/s41580-021-00418-x ?
When D3 came out initially in the 1920's people were dosing 25mg daily (1,000,000iu). Not many got sick and I'm sure some developed hypercalcemia. Then it was changed from mg to IU to confuse people. A study was done in Minnesota tracking 11,000 patients for seven years. One person developed hypercalcemia taking 40,000iu D3 daily, but she was also taking a calcium supplement which she should not have been. She stopped the calcium and she recovered. No one has died from D3. Vitamin D is a cofactor (Gc protein MAF) in making macrophages (white blood cell PacMan). Low D low immune system.
I asked this question because I read on Substack that D3 was Rat Poison. And that they didn’t test for real D3 produced by the body. That they tested for synthetic only. So confusing.
I do get sunshine. I try and get 15 minutes a day.
We should try to avoid smearing nasty compounds on our skin. Dr Furhman uses the phrase "eat the sunscreen' which can be translated as "eat the rainbow" of plants that will protect your skin via the polyphenols they contain. Catch those rays
But if people die of something they don't live to tell the tale about what they took. Someone I know in France took vit D3 supplements and had serious heart complications. It took him a while to figure out the link but that's when he found it was in D-Con rat bait. He recovered as soon as he stopped the D.
Yes D3 in extremely high doses may kill rats due to hypercalcemia. Very high doses in humans can cause hypercalcemia. Relating D3 to a heart problem for one person is vague. Dr Coimbra uses D3 in high doses (600,000iu) D3 if they have to go into the hospital. Most of our cells in our body have vitamin D receptors including our brain. D is required to make macrophages. Low D 25hydroxy low immune system. If a person is also deficient in iodine you have a perfect storm of diseases and cancer.
Hi Stuart, You may be referring to "Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience"
Patrick J McCullough, Douglas S Lehrer and Jeffrey Amend.
Journal of Steroid Biochemistry and Molecular Biology 2019-01-04
https://sci-hub.se/10.1016/j.jsbmb.2018.12.010. This reports on extensive vitamin D3 supplementation in a psychiatric hospital in Cincinnati, Ohio. Dr McCullough takes ca. 1.25 mg (50,000 IU) vitamin D3 a day to suppress psoriasis. Please see my other reply for more on the Coimbra Protocol.
I am not asking anyone to believe or trust me. Belief is a state of mind that obscures the truth. I emphatically request nobody believes me OR trusts me. "Distrust but verify”. Perhaps I can point people who have true curiosity in the direction of rigorous science that is hidden from most of us. I used to believe in viruses, contagion and supplements etc but being retired against my will and having time to read turned out to have some health benefits like avoiding injections and not being afraid of people with a sniffle.
Yes I am absolutely certain viruses are as fictional as purple unicorns. I don't think we can just declare viruses exist unless we have some evidence following the scientific process.
Let's start at the very beginning. The 'Do Re Me' approach. Can diseases be transmitted from sick people to healthy people as we have been brainwashed to believe? Or in a more rigorous format...
Has anyone falsified the null hypothesis "diseases are not spread from ill people to well people"? In his recent book Dan Roytas reviewed 203 studies stretching back well over 100 years and did not find anything that could falsify this hypothesis. In other words, there's no proof that disease is spread by a to healthy people except by the nocebo effect or self-fulfilling prophecy (with the rare exception of a sneeze containing histamines etc.)
If, one day, we found proof of disease transmission by a microorganism then we could set up the next logical null hypothesis "disease is not spread by any microorganism" . (virus, bacteria, etc). So far however, not a single Institution in the world can answer any Freedom of Information request providing documented proof of the isolation and characterisation of a nano-sized particle ('virus') shown to cause sickness.
To explore that further check out Christine Massey's substack. If 255 global institutions like the CDC, Pasteur, Koch etc all confess to not having proof of a virus or a genome for any so-called viral disease then I wonder if you are sitting on that data?
Other great resources are 'Virus Mania’. ‘What Really Makes You Ill” and all of Sam & Mark Bailey’s output. I have much more, let me know when you are ready.
Yes, I am aware of bacteriophages and especially the work of Dr. Stefan Lanka. They exist!
You talk about a "variety of SARS viruses" Are you aware that there is no universally agreed upon definition of “variety” or "variant" or "strain" or "isolate"?
Who said this? 'Mr Virology' himself, Prof. Vincent Racaniello, who wrote 'Principles of Virology', 5th Edition. he said it’s “not even in my textbook”. These Hollywood horror words were invented for the psyop and transmitted by a willing media.
I was in the garden today harvesting my fresh greens, green onions and radishes. Supermarket lettuce has lost 90% of its vitamin C by the time it gets to your table. Also ~30% of many other nutrients. My shirt was off so I could bathe in the rays! I got a whole cupboard of supplements through my skin and eyes. Be well.
If a doctor test for vitamin D3 what he testing for? Is he test for the synthetic man made vitamin D3 or is he/her testing for the real deal? Can the real deal even be tested for?
Vitamin D3 cholecalciferol produced in the skin by the action of ca. 293 nanometre ultraviolet B light on 7-dehydrocholesterol is the exact same molecule as the vitamin D3 found in supplements. The same process is used to manufacture pharmaceutical vitamin D3. 7-dehydrocholesterol is created from wool fat and dissolved in a hydrocarbon liquid and exposed to intense UV-B from large, specially constructed, mercury vapour lamps. See Industrial Aspects of Vitamin D by Arnold L. Hirsch in 2010: https:// sci-hub.se/10.1016/B978-0-12-381978-9.10006-X .
Ingested or UVB >> skin produced vitamin D3 is hydroxylated, primarily in the liver, so that about 1/4 of it is converted into 25-hydroxyvitamin D3 (for brevity I usually leave off the '3') which circulates in the bloodstream. This is what is tested in "vitamin D" blood tests. This is the raw material which immune system needs to run properly and for the kidneys to perform their role in regulating calcium-phosphate-bone metabolism. The kidneys do this by maintaining a very low, 0.05 to 0.1 ng/mL, level of circulating 1,25-dihydroxyvitamin D3 calcitriol, which functions as a hormone (a long-distance, blood-borne, signaling molecule) to affect the behavior of several types of cell which are involved in calcium-phosphate-bone metabolism.
Many types of immune cells, and some other cell types, need a good supply of 25-hydroxyvitamin D, by diffusion from the bloodstream, as the raw material for their intracrine (inside each cell) and paracrine (to nearby cells) signaling systems. These are not well known to doctors or immunologists, because they have been discovered only in the last two decades and because there is no peer-reviewed tutorial on how they work. I wrote a tutorial - not peer reviewed: https://vitamindstopscovid.info/02-intracrine/.
Neither vitamin D3 or 25-hydroxyvitamin D3 are hormones. These are not signaling molecules. The immune system does not use hormonal signaling.
For some obscure reason, doctors in the USA frequently prescribe vitamin D2, rather than the natural vitamin D3. Vitamin D2 ergocalciferol is similar to vitamin D3, but the molecules are not identical. It is made by UV-B irradiating a compound which is produced by yeast. Vitamin D2 is hydroxylated, mainly in the liver to circulating 25-hydroxyvitamin D2, which is further hydroxylated, just like the D3 version, into 1,25-dihydroxyvitamin D2 which acts as a hormone (when in circulation, produced by the kidney) or as an intracrine or paracrine agent in many types of immune cell, like 1,25 hydroxyvitamin D3.
The ability of ingested vitamin D2 to raise circulating 25-hydroxyvitamin D2 levels is inferior to the ability of ingested vitamin D3 to raise circulating 25-hydroxyvitamin D levels. I recall that there are other deficiencies, such as the D2 calcitriol being less able to bind to the "vitamin D receptor" molecule, which is really the "calcitriol receptor". This binding leads to the bound complex finding its way to the nucleus, where it binds to a retinol X molecule and the triple complex altering gene expression (copying the information in particular genes to messenger RNA, which controls protein synthesis and so cell behavior).
Vitamin D2 is also used in some fortified food.
Food fortification, with vitamin D3 or D2, can only provide a small fraction of the 25-hydroxyvitamin D3 (or less effective 25-hydroxyvitamin D2) needed for full immune system function: https://vitamindstopscovid.info/00-evi/#07-fortif.
There is very little vitamin D in food, including foods which are fortified with vitamin D3 or the less effective vitamin D2. Vitamin D3 can be produced in substantial quantities from UV-B exposure of ideally white skin, but this is not naturally available all year round to most people who live far from the equator, since it requires sunshine in the middle of summer days - not early in the morning or late in the afternoon. In a given day, there is no extra benefit of being exposed to about 1/3 of the amount of UV-B which is required to redden the skin.* However, all such exposure exposes the DNA in the skin to damage. There are health benefits from exposure to sunshine, but to rely entirely on UV-B skin exposure to attain the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D the immune system needs to function properly would also greatly raise the risk of skin cancer.
Consequently, most people cannot be fully healthy without proper vitamin D3 supplementation in quantities, which while small, are 5 to 10 or more (for those suffering from obesity) the minuscule 1000 IU (25 micrograms) per day quantities many doctors recommend.
If we had no supplemental vitamin D3, health would be optimized by some level of UV-B skin exposure which trades off the skin cancer risk against the essential benefits of improving immune system function by raising 25-hydroxyvitamin D levels. However, since supplemental vitamin D3 is so inexpensive and readily available, the best approach is to supplement properly and avoid excessive UV-B exposure.
* Determining an Effective UV Radiation Exposure Time for Vitamin D Synthesis in the Skin Without Risk to Health: Simplified Estimations from UV Observations, Masaatsu Miyauchi and Hideaki Nakajima, Photochemistry and Photobiology 2016-10-18 https:// onlinelibrary.wiley.com/doi/10.1111/ php.12651.
Skin cancer awareness is much higher here in Australia than in most other countries. Even if we could get enough UV-B light all year round to attain the 50 ng/mL circulating 25-hydroxyvitamin D3 our immune systems need to function properly - which would require living in the tropics or using special lamps in winter, further from the equator - this would greatly raise the risk of skin cancer.
There are doctors here who do nothing but exceedingly detailed skin examinations, with computerised records to do easy comparisons between multiple examinations.
Most people I know of my age (69) have had spots. lumps, deep growths and the like removed, I assume for perfectly good reasons. Some get regular examinations to detect problems while they are relatively small.
You can find research articles on questions easily with Google Scholar: https:// scholar.google.com.au/schhp . I tried: "skin cancer" surfers
"Surfers and swimmers had consistently higher rates of PSC (pre-skin cancer: actinic keratosis), NMSC (non-melanoma) and MSC (melanoma skin cancers) than the general Australian population. Point prevalence of MSC (groups combined) was 76-fold higher than the general Australian population."
The pattern of locations on the bodies of surfers shows that this is due to the UV-B exposure - mainly the face, arm and back. These people might have less trouble with cancer if their vitamin D3 levels were high all year round, but a lot of this intense UV-B exposure is in summer, with precancerous cells not properly suppressed by the immune system when summer is over, and 25-hydroxyvitamin D levels drop well below 50 ng/L, in the absence of proper vitamin D3 supplements, during winter and spring.
Dr Pierer Kory and Dr Paul Marik also pioneered the use of high dose ascorbic acid to treat septic shock...
"In collaboration with Dr. Paul Marik, Dr. Kory pioneered the research and treatment of septic shock
patients with high doses of intravenous ascorbic acid. His work was the first to identify the critical
relationship between the time of initiation of therapy and survival in septic shock patients, an aspect of the therapy that led to understanding all the failed randomized controlled trials that employed delayed therapy."
Vitamin C seems to have been studied in 2020 by Dr. Kory - about when the perpetrators started the psyop. I remember Kory was pushing Ivermectin as an 'anti-viral' so I was wondering out loud if there could be a connection.
Ivermectin, like anything, even aspirin can be a problem when over used. I've used it a few times to test in case I needed to give it to family. I went with the typical dose which is calculated by weight on the 🐴 package 😂.
No side effects nor anything noticeable.
I would also be wary of using it more than a couple of days as levels can build up.
Same with vitamin C, for some people high levels can lead to too high iron levels (hemochromatosis).
Everyone is different but unfortunately the medical system treats us like the same model of machines 😢.
Peter, It’s not ME talking it’s that darn internet. There is a connection to vit C too
"Ivomec is a pour-on wormer for cattle. The pioneer in broad spectrum pour-on ivermectin parasite control for cattle, Ivomec provides proven results in the treatment and control of roundworms, lungworms, grubs, horn flies, sucking and biting lice, and sarcoptic mange. “ So what do you think? insecticide - or harmless micronutrient?
Now I will show that both Ivermectin and septic shock lead to kidney damage. Not exactly the same pathogenesis perhaps, but I want to illustrate the similarity.
Rat Study: "Results showed that administration of ivermectin led to attenuation in kidney function and in activities of the antioxidant enzymes and increase in matrix metalloproteinase-9 activity. In addition, there were histological damages (shrunken glomeruli, widened urinary space, cytoplasmic vacuolation and pyknotic nuclei with epithelial exfoliation, extravasated blood, and mononuclear cell infiltration) and immunohistochemistry revealed increase in percentage of Bax proapoptotic protein expression. Also, ultrastructure examination showed alteration in cell architecture.
"Septic shock, a severe complication of sepsis, can lead to kidney damage, known as s-AKI or sepsis-associated acute kidney injury. Sepsis is a life-threatening response to infection where the body's inflammatory response goes awry, damaging organs, including the kidneys.”
There IS a connection to vitamin C here because that rat study proposed that it could be used to attenuate Ivermectin damage to the kidneys! Crazy.
Just one more observation: the two co-reactants for Ivermectin synthesis happen to be from bacterial fermentation. Septic shock is said to arise from bacteria derived endotoxin! Interesting eh?
Yes, bacteria derived endotoxin but why do the bacteria proliferate?
Right now you have strep A in your throat but you're fine. You have ecoli in your digestive system but you're fine.
Bacteria multiply when there's dead matter for them to feed on. Yes, they have byproducts like endotoxins, but the goal is not to kill the bacteria but help with elimination of the dead matter and of the toxin buildup.
I get the same message from the research. Bacteria do not cause or transmit disease. They are the opportunistic clean up crew. However in severe cases of tissue damage the bacteria could overwhelm what the body is trying to do or cause a dangerous blockage in which case it's best to take an antibiotic. But only in an extreme circumstance and only for a short stretch. Are we close?
I like the level of detail this doctor and you, Roman, included in your descriptions of treatment. Amazing how much simpler it appears than when interventions are put in allopathic clinical jargon. And when you review the horrific story of scurvy (as you have elsewhere) and realise how simple the cure and preventative for that horrific condition, viz vit c delivered via fresh or suitably preserved vit c-rich food, you can rest assured there are plenty more very simple cures and preventatives for all sorts of things if people eat well and are sensible to body needs.
Common sense needs to be supported. It has been made to seem second-class by those who would benefit from nudging us into mysterious concoctions for profit.
Way back in 1536 Jacques Cartier ship got stuck in winter ice near Montreal. His crew start dying from some weird disease. A local Indian saw what was happening and gave them brewed pine needle tea. Most recovered. Mr Cartier went back to France and told his superiors and would not listen. Of course it was scurvy caused by lack of C.
All of the members of our farm ministry learn about Klenner’s Vitamin C Baby protocol. To withhold this information from pregnant women is a crime against humanity that rivals quack-sin-ation.
Interesting I have been trying this just aurally when I get cold symptoms and within 48-72 hours the symptoms have gone, I find you can tell when the vit c is starting to wear off and and a top up of 1-2000 mg soon sorts them out
You can add sepsis to the list. Dr Levy in his book explains when the vitamin C dose is high enough it triggers the Fenton Reaction which forces the intercellular H2O2 to release its single bond oxygen atom and thereby becoming an oxidant. Dr Paul Marik has used this to cure sepsis.
Is it scientifically correct to make the equation VitaminC=AscorbicAcid? And how is "vitamin C in powder form" produced, as I doubt it is from ground dried lemons...
I appreciate the article and apologies for being a curmudgeon (the role nature has conferred upon me).
Alternative Hypothesis: What if L-Ascorbic acid was preventing the body's natural elimination methods that we call "disease"?
If you prevent the body from eliminating toxins through the skin (preventing Measles) by administration of a concentrated extract like vit. C or Vit. A etc. then what happens to those poisons? For example, are they transported to the liver for elimination via bile or do they get rolled up into a tumour to be discovered later?
Daniel Roytas said that to prevent scurvy the whole fruits and plants were much more effective than this one extracted compound. We have ignored hundreds of other compounds in the citrus or other plants in order to promote a pill containing just a single compound.
The only magic pill that I have personally investigated that has any benefit is mineral water that is rich in silicon. This is for removal of aluminum and restoration of a sound mind (a friend with early Alzheimer's and a grandson with mild autism symptoms fully and partially recovered respectively).
What happens when Vitamin C cures a disease, any disease? The cure is simply ignored. If we check the medical references, MERCK, Langes, Harrisons, and Ferris - all suggest Vitamin C as a "treatment" for scurvy. The word "cure" is not used. In addition, there is no cure offered for Vitamin C deficiency. Vitamin C is not recognized as the cure for Vitamin C deficiency. Not only that, it cannot be approved as a cure - it does not qualify. In addition, CURED is simply not defined medically for Vitamin C deficiency, and CURED is not medically defined for scurvy. There is no medical test for Vitamin C deficiency cured. There is no medical test for scurvy cured.
It is not possible to prove than any case of disease has been cured by Vitamin C today.
We should not be surprised that Vitamin C is not recognized as a cure for many other diseases. It is simply not permitted to cure.
You could look for a place near you that offers vitamin infusions. From the website of a center near me: ..In general, high dose vitamin C infusions are administered 2-3 times week. A G6PD blood test is required prior to starting the treatments.
Depending upon the situation they may be able to tailor the protocol so that an adequate amount of vitamin C is utilized.
Curing the Incurable is an excellent book about vitamin C, and Dr. Klenner is featured many times in it.
https://a.co/d/eycp8nr
How do we find doctors who will administer vitamin C?
One thing you can do right away is look at how you can get vitamin C (and other important nutrients) into your diet. Here is one way:
7 Health Benefits of Kakadu Plum
https://substack.com/@romanbystrianyk/note/c-105460701
Thank you so much for this information.
You can get ascorbic acid powder and take the same amount orally dissolved in water.
https://beyondhealth.com/blog/taking-vitamin-c-to-bowel-tolerance/
https://vitamincfoundation.org/www.orthomed.com/titrate.htm
Thank you!
High dose vitamin C may well be an important treatment for some acute conditions, but by far the most important and easily corrected nutritional deficiency is that most people have only a fraction of the 50 ng/mL circulating 25-hydroxyvitamin D their immune system needs to function properly.
Please read the research articles cited and discussed at: https://vitamindstopscovid.info/00-evi/ .
The best approach is to supplement vitamin D3 in sufficient quantities to attain this. This takes several months at healthy average daily intakes such as 125 micrograms (5000 IU) for 70 kg (154 lb) body weight without obesity. The above page starts with recommendations from New Jersey based Professor of Medicine Sunil Wimalawansa on how much vitamin D3 to supplement, on average, per day, in order to safely attain at least the 50 ng/mL circulating 25-hydroxyvitamin D the immune system needs, without the need for blood tests or medical monitoring.
Bolus (single, large AKA "loading") vitamin D3 is the most common approach to boosting low levels, such as 15 ng/mL or less to 50 ng/mL or more in clinical emergencies.
There is an urgent, hour-to-hour, need to raise circulating 25-hydroxyvitamin D to 50 ng/mL or more in all cases of sepsis, Kawasaki disease, MIS-C, severe or potentially severe COVID-19, influenza, ARDS etc. In cancer, the urgency is somewhat less, but it is still vital to enable the immune system to function properly, including by reducing the risk of self-destructive, overly inflammatory, immune responses.
The ESPEN (European Society for Clinical Nutrition and Metabolism) guideline on clinical nutrition in the intensive care unit, Singer et al. 2014: Clinical Nutrition https://www.sciencedirect.com/science/article/pii/ S0261561418324324 states that "a single high dose (500,000 IU) can be administered in the first week and seems safe in patients with deficiency." Most people are deficient with respect to 50 ng/mL circulating 25-hydroxyvitamin D.
A smaller amount, according to body weight, would be appropriate for infants and children.
This vitamin D3 takes a few days to be hydroxylated, mainly in the liver, to the circulating 25-hydroxyvitamin D the immune system needs. (Only about 1/4 of ingested or UV-B -> skin produced vitamin D3 becomes this circulating 25-hydroxyvitamin D.)
The best approach, as recommended by Prof. Wimalawansa, is a single oral dose of about 1 mg of calcifediol (for 70 kg body weight). Calcifediol *is* 25-hydroxyvitamin D. This is easily absorbed and goes straight into circulation in the bloodstream. This will raise the 25(OH)D level safely over 50 ng/mL in about 4 hours. https://vitamindstopscovid.info/00-evi/#4.7.
Good information on D3! It’s not just vitamin C but also, as you say, D3, which I often recommend lots of sunshine (subject to the time of year) and magnesium, which we are woefully deficient in. https://romanbystrianyk.substack.com/p/the-magnesium-deficiency-crisis
My top 3 are D3, magnesium and Lugols iodine. 95% of us are iodine deficient, (Dr David Brownstein). Both iodine and D3 are needed for our immune system.
Very good. Dr Coimbra (Coimbra Protocol) uses high dose D3 to alleviate symptoms of MS, autism, Parkinsons, Alzheimer's, etc. Most of our cells in our body have vitamin D receptors, including our brain. Since low dose D3 takes 3 months to increase in our body he does a one time dose of 600,000iu D3 for patients that have to go in the hospital since it bumps up faster. He has now incorporated Dr Christopher Exley (Substack) protocol of chelating aluminum from our body with mineral water high in silica. For some strange reason we have a high toxicity of aluminum in our brains.
Dr Coimbra explaining to Dr Berg his protocol.
https://youtu.be/cmPEA0EWd7g?si=0ZXwRtTUeY3w-OH5
Thanks very much for the link to the recent interview with Dr Cicero Coimbra and to the work of Dr Christopher Exley.
I found this page, which I think leads to Dr Exley's work on silicic acid to remove aluminium from the body: https://drchristopherexley.substack.com/p/all-heal-silicic-acid. This links to a video: https://www.youtube.com/watch?v=1GB_MNIdg_k&t=480s which mentions an article in Nature: https://scholar.google.com.au/scholar?hl=en&as_sdt=0,5&q=%22Acute+toxicity+of+Aluminium+to+fish+eliminated%22 . The PDF is at: https://sci-hub.se/10.1038/338146a0. This looks very interesting.
Dr Coimbra and the German doctors who treat patients with his protocol: https://www.mdpi.com/2072-6643/14/8/1575 propose that the high vitamin D3 intake suppressed autoimmune inflammatory disorders by overcoming a very vaguely described "vitamin D resistance", such as some kind of problem absorbing vitamin D3. This makes no sense, since the levels of 25-hydroxyvitamin D they reach are very high, and are typically, at least for treating multiple sclerosis, borderline or actually toxic, unless special precautions are taken to minimise calcium intake. The protocol takes this level way out of observed range of natural levels - up to 70 ng/mL or so - into the hundreds of ng/mL.
They don't seem to be aware that the inflammatory disorders they are tackling are caused in large part by our lack of helminths. A substack comment is not the place to explain this properly, so please see: https://vitamindstopscovid.info/06-adv/ and in particular the end of this section https://vitamindstopscovid.info/06-adv/#cc.
I need to update this, because when I wrote it I did not have a hypothesis as to why the Coimbra Protocol's very high 25-hydroxyvitamin D levels suppressed the excessive, inflammatory (self destructive, indiscriminate, cell destruction).
I now have a hypothesis. I should write to Dr Coimbra and the German doctors about this. See the end of my "(2 of 3)" comment at: https://www.aporiamagazine.com/p/beauty-as-a-biological-construct. I need to develop this some more. Briefly, the very high level of circulating 25-hydroxyvitamin D, raises, by diffusion, the level of 25-hydroxyvitamin D in the cytosol (the fluid inside) all cells, including the cytosol of Th1 regulatory lymphocytes.
Chauss et al. did beautiful work elucidating the intracrine (they called it "autocrine") signaling system in Th1 lymphocytes by which an initially inflammatory state (their "startup program") of these cells (putting out more of a pro-inflammatory cytokine than of an anti-inflammatory cytokine) is normally reversed when a condition (a high level of a complement protein) is detected. This activates the 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D (calcitriol) intracrine signaling system inside the cell, which creates intracellular calcitriol which then binds to the "vitamin D" receptor molecule (really the calcitriol receptor molecule) which the activated intracrine signaling system also creates, or at least raises the level of, in the cytosol. The resulting bound complex binds, in the nucleus, with retinol X and the triple complex alters gene transcription in cell-type specific ways, up- and down-regulating the transcription of dozens to hundred of genes. Which genes are up- and down-regulated when calcitriol binds to the VDR molecule varies greatly from one cell type to the next. Likewise, for those cells which have such an intracrine signaling system, the condition which activates also varies greatly from one cell type to the next. (These systems are not related to hormonal signalling.)
A summary of Chauss et al. https://www.nature.com/articles/s41590-021-01080-3 is at: https://aminotheory.com/cv19/icu/#2021-Chauss. See also my tutorial (because I could not find any such introductory explanation at all) of 25-hydroxyvitamin D >> calcitriol intracrine and paracrine signaling: https://vitamindstopscovid.info/02-intracrine/.
In the case of Th1 lymphocytes, the gene expression changes alter protein synthesis in ways which alter the behavior of the cell so it switches to an anti-inflammatory shutdown program: producing less of the pro-inflammatory cytokine and more of the anti-inflammatory cytokine.
My explanatory hypothesis for the Coimbra (and McCullough and Batchelor) Protocol(s) is that the very high level of 25-hydroxyvitamin D in the cell causes a significant amount of 25-hydroxyvitamin D binding to a presumed background level of "vitamin D" receptor (VDR) molecules at all times. This is because although the VDR molecule has a high binding affinity with calcitriol, it has also has an affinity to bind with 25-hydroxyvitamin D, albeit a much lower affinity. I propose that the very high level of 25-hydroxyvitamin D causes sufficient binding to VDR molecules that the anti-inflammatory pattern of gene expression is always enabled.
Lou et al. 2010 https://www.sciencedirect.com/science/article/abs/pii/S0960076009002829 https://sci-hub.se/10.1016/j.jsbmb.2009.11.011 report: "The VDR binds calcitriol with high affinity (Kd-value of 0.1 nM), whereas 25-hydroxyvitamin D binds to human VDR approximately 50 times less effectively."
So, in people with very high (150 ng/mL or more) 25-hydroxyvitamin D levels, as the Coimbra Protocol often achieves, I propose that their Th1 lymphocytes can never be in their startup program of being pro-inflammatory, even when these cells first begin their existence - or at least 25-hydroxyvitamin D binding to the VDR molecule this happens to some extent which is sufficient to suppress the worst of the excessive inflammation which causes these auto-immune inflammatory conditions.
Thx. I found it amazing that Dr Bruce Hollis did an FDA approved study back in the 90’s showing 4,000iu (max allowed by FDA) D3 daily shrank prostate tumors during a 3 month period. He also noted the has the ability to convert 25 hydroxy to 1,25 dihydroxy.
Robin, yes Exley's book is excellent as are all his papers. Some rare actual science. For serious readers or researchers it needed an index so I compiled a detailed one. It's in PDF format. It was posted on his substack but not updated. Let me know if you are interested - then we will work out a way to get it to you or anyone interested.
I have a question about the vit D family. When we see an association between low Vitamin D and illness does that mean that low Vit D CAUSED the illness or is the reverse true: does the illness cause a decrease in Vit D like compounds - is this part of a necessary biochemical dance?
Does supplementation during this illness cure the disease? Dr Tom Cowan did a review of about 40 papers on Vit D indicating we might be victims of the association = causation trap that the human brain is designed to fall into! This might be on BitChute.
BTW good point about helminths. Cheers
Hi Dave, You can email the PDF to me at rw@firstpr.com.au.
A 2019 article by Chris Exley and colleagues, "Silicic acid: The omniscient molecule" is at: https://sci-hub.se/https://doi.org/10.1016/j.scitotenv.2019.02.197 .
25-hydroxyvitamin D (as tested in "vitamin D" blood tests) is needed to supply many types of immune cell which need it for intracrine (inside each cell) and paracrine (to nearby cells) signaling. Please see my tutorial on these signaling systems at: https://vitamindstopscovid.info/00-evi/#02-compounds. All medical professionals, immunologists etc. and anyone seriously interested in health needs to understand these, but few have ever heard of them.
There is limited evidence of 25-hydroxyvitamin D levels dropping with severe illness. This is easily misinterpreted as being a bigger effect than what actually happens, as far as I can tell. I don't recall the research, but there was one trial in which a strong inflammatory response was induced, I think with bacterial toxins, and a modest drop in 25-hydroxyvitamin D was measured.
This does not alter the numerous observations which indicate that 50 ng/mL 125 nmol/L circulating 25-hydroxyvitamin D is needed for full immune system function, and that rapidly boosting this in serious infections, including sepsis, helps the patient recover.
Please spend a couple of hours reading https://vitamindstopscovid.info/00-evi/ and looking at some or all of the research I cite. Then you will have a good understanding of these signaling systems and why 50 ng/mL or more circulating 25-hydroxyvitamin D is so important for health. You will then see that this is not related to hormonal signaling and that it is important to refer to the three compound clearly at all times - they are not all "vitamin D":
Vitamin D3 cholecalciferol.
25-hydroxyvitamin D calcifediol AKA "calcidiol".
1,25 dihydroxyvitamin D calcitriol.
Yes, but strictly High in silicic acid Si(OH)4 not silica SiO2. I am clarifying this point because many people think they can buy a silica product and recover from Dementia and the other 37 diseases linked to/caused by aluminum.
I just follow Dr Christopher Exley (Substack) protocol of using mineral water with over 30mg/l of silica. I know others are also adding silica to water but I am not sure of what type.
First there is no such thing as Covid 19. That was all made up. I recommend 'Can You Catch A Cold?' and 'Virus Mania'
Also be careful not to overdose on D. More is NOT better. This sounds dramatic but worth knowing especially if you have pets that might chomp on tasty morsels of D-Con.
Vitamin D or cholecalciferol is the main ingredient in rat poison.
Here is cholecalciferol on Pubchem. https://pubchem.ncbi.nlm.nih.gov/compound/Cholecalciferol#section=Chemical-Vendors
Check out section 14 for example on all the toxic effects.
Here is calcifidiol
https://pubchem.ncbi.nlm.nih.gov/compound/Calcifediol
Here is the Merck Manual entry
https://www.merckvetmanual.com/toxicology/rodenticide-poisoning/cholecalciferol-vitamin-d3-poisoning-in-animals
Brought to you by Sunshine!
Be well
Anyone who is tempted to believe what DDR Dave wrote about vitamin D3 cholecalciferol and 25-hydroxyvitamin D calcifediol should read the research cited and discussed at: https://vitamindstopscovid.info/00-evi/.
If we ate the same quantity of vitamin D3, as a ratio of body weight, as rats, we too would die a horrible death. This doesn't alter the fact that in order to attain the 50 ng/mL or more circulating 25-hydroxyvitamin D our immune systems need to function properly, that we need to ingest ca. 125 micrograms of vitamin D3 a day, on average (for 70 kg body weight without obesity) OR generate it ourselves with large amounts of UV-B exposure of ideally white skin, which is impractical and always damages DNA and so raises the risk of skin cancer.
Of course viruses exist, as does the now large variety of SARS-CoV-2 viruses, which infect, harm and sometimes kill people. Do you think all this is entirely made up: https://www.nature.com/articles/s41580-021-00418-x ?
What about bacteriophages? You can see electron micrographs of them - viruses that replicate in bacteria: https://www.mdpi.com/2079-6412/13/3/609 .
When D3 came out initially in the 1920's people were dosing 25mg daily (1,000,000iu). Not many got sick and I'm sure some developed hypercalcemia. Then it was changed from mg to IU to confuse people. A study was done in Minnesota tracking 11,000 patients for seven years. One person developed hypercalcemia taking 40,000iu D3 daily, but she was also taking a calcium supplement which she should not have been. She stopped the calcium and she recovered. No one has died from D3. Vitamin D is a cofactor (Gc protein MAF) in making macrophages (white blood cell PacMan). Low D low immune system.
Oh 😮
Fantastic response. Thank you so much.
I asked this question because I read on Substack that D3 was Rat Poison. And that they didn’t test for real D3 produced by the body. That they tested for synthetic only. So confusing.
I do get sunshine. I try and get 15 minutes a day.
We should try to avoid smearing nasty compounds on our skin. Dr Furhman uses the phrase "eat the sunscreen' which can be translated as "eat the rainbow" of plants that will protect your skin via the polyphenols they contain. Catch those rays
Hmmm, not. I’m a carnivore. I don’t eat plants. Nor do I use sunscreen. I never have. Sun bunny for life.
But if people die of something they don't live to tell the tale about what they took. Someone I know in France took vit D3 supplements and had serious heart complications. It took him a while to figure out the link but that's when he found it was in D-Con rat bait. He recovered as soon as he stopped the D.
Yes D3 in extremely high doses may kill rats due to hypercalcemia. Very high doses in humans can cause hypercalcemia. Relating D3 to a heart problem for one person is vague. Dr Coimbra uses D3 in high doses (600,000iu) D3 if they have to go into the hospital. Most of our cells in our body have vitamin D receptors including our brain. D is required to make macrophages. Low D 25hydroxy low immune system. If a person is also deficient in iodine you have a perfect storm of diseases and cancer.
Hi Stuart, You may be referring to "Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience"
Patrick J McCullough, Douglas S Lehrer and Jeffrey Amend.
Journal of Steroid Biochemistry and Molecular Biology 2019-01-04
https://www.sciencedirect.com/science/article/abs/pii/S0960076018306228 (Paywalled.)
https://sci-hub.se/10.1016/j.jsbmb.2018.12.010. This reports on extensive vitamin D3 supplementation in a psychiatric hospital in Cincinnati, Ohio. Dr McCullough takes ca. 1.25 mg (50,000 IU) vitamin D3 a day to suppress psoriasis. Please see my other reply for more on the Coimbra Protocol.
Thank-you for the clarification.
I am not asking anyone to believe or trust me. Belief is a state of mind that obscures the truth. I emphatically request nobody believes me OR trusts me. "Distrust but verify”. Perhaps I can point people who have true curiosity in the direction of rigorous science that is hidden from most of us. I used to believe in viruses, contagion and supplements etc but being retired against my will and having time to read turned out to have some health benefits like avoiding injections and not being afraid of people with a sniffle.
Yes I am absolutely certain viruses are as fictional as purple unicorns. I don't think we can just declare viruses exist unless we have some evidence following the scientific process.
Let's start at the very beginning. The 'Do Re Me' approach. Can diseases be transmitted from sick people to healthy people as we have been brainwashed to believe? Or in a more rigorous format...
Has anyone falsified the null hypothesis "diseases are not spread from ill people to well people"? In his recent book Dan Roytas reviewed 203 studies stretching back well over 100 years and did not find anything that could falsify this hypothesis. In other words, there's no proof that disease is spread by a to healthy people except by the nocebo effect or self-fulfilling prophecy (with the rare exception of a sneeze containing histamines etc.)
If, one day, we found proof of disease transmission by a microorganism then we could set up the next logical null hypothesis "disease is not spread by any microorganism" . (virus, bacteria, etc). So far however, not a single Institution in the world can answer any Freedom of Information request providing documented proof of the isolation and characterisation of a nano-sized particle ('virus') shown to cause sickness.
To explore that further check out Christine Massey's substack. If 255 global institutions like the CDC, Pasteur, Koch etc all confess to not having proof of a virus or a genome for any so-called viral disease then I wonder if you are sitting on that data?
Other great resources are 'Virus Mania’. ‘What Really Makes You Ill” and all of Sam & Mark Bailey’s output. I have much more, let me know when you are ready.
Yes, I am aware of bacteriophages and especially the work of Dr. Stefan Lanka. They exist!
You talk about a "variety of SARS viruses" Are you aware that there is no universally agreed upon definition of “variety” or "variant" or "strain" or "isolate"?
Who said this? 'Mr Virology' himself, Prof. Vincent Racaniello, who wrote 'Principles of Virology', 5th Edition. he said it’s “not even in my textbook”. These Hollywood horror words were invented for the psyop and transmitted by a willing media.
https://www.youtube.com/watch?v=G2G2bWUAef0
I was in the garden today harvesting my fresh greens, green onions and radishes. Supermarket lettuce has lost 90% of its vitamin C by the time it gets to your table. Also ~30% of many other nutrients. My shirt was off so I could bathe in the rays! I got a whole cupboard of supplements through my skin and eyes. Be well.
If a doctor test for vitamin D3 what he testing for? Is he test for the synthetic man made vitamin D3 or is he/her testing for the real deal? Can the real deal even be tested for?
Vitamin D3 cholecalciferol produced in the skin by the action of ca. 293 nanometre ultraviolet B light on 7-dehydrocholesterol is the exact same molecule as the vitamin D3 found in supplements. The same process is used to manufacture pharmaceutical vitamin D3. 7-dehydrocholesterol is created from wool fat and dissolved in a hydrocarbon liquid and exposed to intense UV-B from large, specially constructed, mercury vapour lamps. See Industrial Aspects of Vitamin D by Arnold L. Hirsch in 2010: https:// sci-hub.se/10.1016/B978-0-12-381978-9.10006-X .
Ingested or UVB >> skin produced vitamin D3 is hydroxylated, primarily in the liver, so that about 1/4 of it is converted into 25-hydroxyvitamin D3 (for brevity I usually leave off the '3') which circulates in the bloodstream. This is what is tested in "vitamin D" blood tests. This is the raw material which immune system needs to run properly and for the kidneys to perform their role in regulating calcium-phosphate-bone metabolism. The kidneys do this by maintaining a very low, 0.05 to 0.1 ng/mL, level of circulating 1,25-dihydroxyvitamin D3 calcitriol, which functions as a hormone (a long-distance, blood-borne, signaling molecule) to affect the behavior of several types of cell which are involved in calcium-phosphate-bone metabolism.
Many types of immune cells, and some other cell types, need a good supply of 25-hydroxyvitamin D, by diffusion from the bloodstream, as the raw material for their intracrine (inside each cell) and paracrine (to nearby cells) signaling systems. These are not well known to doctors or immunologists, because they have been discovered only in the last two decades and because there is no peer-reviewed tutorial on how they work. I wrote a tutorial - not peer reviewed: https://vitamindstopscovid.info/02-intracrine/.
Neither vitamin D3 or 25-hydroxyvitamin D3 are hormones. These are not signaling molecules. The immune system does not use hormonal signaling.
For some obscure reason, doctors in the USA frequently prescribe vitamin D2, rather than the natural vitamin D3. Vitamin D2 ergocalciferol is similar to vitamin D3, but the molecules are not identical. It is made by UV-B irradiating a compound which is produced by yeast. Vitamin D2 is hydroxylated, mainly in the liver to circulating 25-hydroxyvitamin D2, which is further hydroxylated, just like the D3 version, into 1,25-dihydroxyvitamin D2 which acts as a hormone (when in circulation, produced by the kidney) or as an intracrine or paracrine agent in many types of immune cell, like 1,25 hydroxyvitamin D3.
However, the D2 versions of these three compounds are less effective than the natural D3 versions: https://www.thieme-connect.com/products/ejournals/abstract/10.4103/ijmbs.ijmbs_8_19.
The ability of ingested vitamin D2 to raise circulating 25-hydroxyvitamin D2 levels is inferior to the ability of ingested vitamin D3 to raise circulating 25-hydroxyvitamin D levels. I recall that there are other deficiencies, such as the D2 calcitriol being less able to bind to the "vitamin D receptor" molecule, which is really the "calcitriol receptor". This binding leads to the bound complex finding its way to the nucleus, where it binds to a retinol X molecule and the triple complex altering gene expression (copying the information in particular genes to messenger RNA, which controls protein synthesis and so cell behavior).
Vitamin D2 is also used in some fortified food.
Food fortification, with vitamin D3 or D2, can only provide a small fraction of the 25-hydroxyvitamin D3 (or less effective 25-hydroxyvitamin D2) needed for full immune system function: https://vitamindstopscovid.info/00-evi/#07-fortif.
There is very little vitamin D in food, including foods which are fortified with vitamin D3 or the less effective vitamin D2. Vitamin D3 can be produced in substantial quantities from UV-B exposure of ideally white skin, but this is not naturally available all year round to most people who live far from the equator, since it requires sunshine in the middle of summer days - not early in the morning or late in the afternoon. In a given day, there is no extra benefit of being exposed to about 1/3 of the amount of UV-B which is required to redden the skin.* However, all such exposure exposes the DNA in the skin to damage. There are health benefits from exposure to sunshine, but to rely entirely on UV-B skin exposure to attain the 50 ng/mL (125 nmol/L) circulating 25-hydroxyvitamin D the immune system needs to function properly would also greatly raise the risk of skin cancer.
Consequently, most people cannot be fully healthy without proper vitamin D3 supplementation in quantities, which while small, are 5 to 10 or more (for those suffering from obesity) the minuscule 1000 IU (25 micrograms) per day quantities many doctors recommend.
If we had no supplemental vitamin D3, health would be optimized by some level of UV-B skin exposure which trades off the skin cancer risk against the essential benefits of improving immune system function by raising 25-hydroxyvitamin D levels. However, since supplemental vitamin D3 is so inexpensive and readily available, the best approach is to supplement properly and avoid excessive UV-B exposure.
* Determining an Effective UV Radiation Exposure Time for Vitamin D Synthesis in the Skin Without Risk to Health: Simplified Estimations from UV Observations, Masaatsu Miyauchi and Hideaki Nakajima, Photochemistry and Photobiology 2016-10-18 https:// onlinelibrary.wiley.com/doi/10.1111/ php.12651.
Skin cancer awareness is much higher here in Australia than in most other countries. Even if we could get enough UV-B light all year round to attain the 50 ng/mL circulating 25-hydroxyvitamin D3 our immune systems need to function properly - which would require living in the tropics or using special lamps in winter, further from the equator - this would greatly raise the risk of skin cancer.
There are doctors here who do nothing but exceedingly detailed skin examinations, with computerised records to do easy comparisons between multiple examinations.
Most people I know of my age (69) have had spots. lumps, deep growths and the like removed, I assume for perfectly good reasons. Some get regular examinations to detect problems while they are relatively small.
You can find research articles on questions easily with Google Scholar: https:// scholar.google.com.au/schhp . I tried: "skin cancer" surfers
The first page of results included Climetein et al. 2022 https:// peerj.com/articles/13243/
"Surfers and swimmers had consistently higher rates of PSC (pre-skin cancer: actinic keratosis), NMSC (non-melanoma) and MSC (melanoma skin cancers) than the general Australian population. Point prevalence of MSC (groups combined) was 76-fold higher than the general Australian population."
The pattern of locations on the bodies of surfers shows that this is due to the UV-B exposure - mainly the face, arm and back. These people might have less trouble with cancer if their vitamin D3 levels were high all year round, but a lot of this intense UV-B exposure is in summer, with precancerous cells not properly suppressed by the immune system when summer is over, and 25-hydroxyvitamin D levels drop well below 50 ng/L, in the absence of proper vitamin D3 supplements, during winter and spring.
*Of course virus’ don’t exist, yes all made up
Any complex system can be optimised for one variable only; never for two or more.
Medicine today is optimised for maximum profit. That makes it impossible to aim for the best patient health outcomes.
Dr Pierer Kory and Dr Paul Marik also pioneered the use of high dose ascorbic acid to treat septic shock...
"In collaboration with Dr. Paul Marik, Dr. Kory pioneered the research and treatment of septic shock
patients with high doses of intravenous ascorbic acid. His work was the first to identify the critical
relationship between the time of initiation of therapy and survival in septic shock patients, an aspect of the therapy that led to understanding all the failed randomized controlled trials that employed delayed therapy."
https://imahealth.org/wp-content/uploads/2021/01/FLCCC-Alliance-member-CV-Kory.pdf
I wonder why patients came down with septic shock. Perhaps from all that insecticide known as ivermectin?
The Marik study was before con-vid.
2017
https://rebelem.com/the-marik-protocol-have-we-found-a-cure-for-severe-sepsis-and-septic-shock/
Vitamin C seems to have been studied in 2020 by Dr. Kory - about when the perpetrators started the psyop. I remember Kory was pushing Ivermectin as an 'anti-viral' so I was wondering out loud if there could be a connection.
https://drsambailey.com/resources/videos/covid-19/the-ivermectin-games/
2017 by Marik. https://rebelem.com/the-marik-protocol-have-we-found-a-cure-for-severe-sepsis-and-septic-shock/
Ivermectin, like anything, even aspirin can be a problem when over used. I've used it a few times to test in case I needed to give it to family. I went with the typical dose which is calculated by weight on the 🐴 package 😂.
No side effects nor anything noticeable.
I would also be wary of using it more than a couple of days as levels can build up.
Same with vitamin C, for some people high levels can lead to too high iron levels (hemochromatosis).
Everyone is different but unfortunately the medical system treats us like the same model of machines 😢.
What are you talking about? People come down with toxic shock for a number of reasons none of them being ivermectin which is not an insecticide.
Peter, It’s not ME talking it’s that darn internet. There is a connection to vit C too
"Ivomec is a pour-on wormer for cattle. The pioneer in broad spectrum pour-on ivermectin parasite control for cattle, Ivomec provides proven results in the treatment and control of roundworms, lungworms, grubs, horn flies, sucking and biting lice, and sarcoptic mange. “ So what do you think? insecticide - or harmless micronutrient?
Now I will show that both Ivermectin and septic shock lead to kidney damage. Not exactly the same pathogenesis perhaps, but I want to illustrate the similarity.
Rat Study: "Results showed that administration of ivermectin led to attenuation in kidney function and in activities of the antioxidant enzymes and increase in matrix metalloproteinase-9 activity. In addition, there were histological damages (shrunken glomeruli, widened urinary space, cytoplasmic vacuolation and pyknotic nuclei with epithelial exfoliation, extravasated blood, and mononuclear cell infiltration) and immunohistochemistry revealed increase in percentage of Bax proapoptotic protein expression. Also, ultrastructure examination showed alteration in cell architecture.
"Septic shock, a severe complication of sepsis, can lead to kidney damage, known as s-AKI or sepsis-associated acute kidney injury. Sepsis is a life-threatening response to infection where the body's inflammatory response goes awry, damaging organs, including the kidneys.”
There IS a connection to vitamin C here because that rat study proposed that it could be used to attenuate Ivermectin damage to the kidneys! Crazy.
Just one more observation: the two co-reactants for Ivermectin synthesis happen to be from bacterial fermentation. Septic shock is said to arise from bacteria derived endotoxin! Interesting eh?
Yes, bacteria derived endotoxin but why do the bacteria proliferate?
Right now you have strep A in your throat but you're fine. You have ecoli in your digestive system but you're fine.
Bacteria multiply when there's dead matter for them to feed on. Yes, they have byproducts like endotoxins, but the goal is not to kill the bacteria but help with elimination of the dead matter and of the toxin buildup.
https://robc137.substack.com/p/fix-the-foundation-before-the-roof
I get the same message from the research. Bacteria do not cause or transmit disease. They are the opportunistic clean up crew. However in severe cases of tissue damage the bacteria could overwhelm what the body is trying to do or cause a dangerous blockage in which case it's best to take an antibiotic. But only in an extreme circumstance and only for a short stretch. Are we close?
I like the level of detail this doctor and you, Roman, included in your descriptions of treatment. Amazing how much simpler it appears than when interventions are put in allopathic clinical jargon. And when you review the horrific story of scurvy (as you have elsewhere) and realise how simple the cure and preventative for that horrific condition, viz vit c delivered via fresh or suitably preserved vit c-rich food, you can rest assured there are plenty more very simple cures and preventatives for all sorts of things if people eat well and are sensible to body needs.
Common sense needs to be supported. It has been made to seem second-class by those who would benefit from nudging us into mysterious concoctions for profit.
Way back in 1536 Jacques Cartier ship got stuck in winter ice near Montreal. His crew start dying from some weird disease. A local Indian saw what was happening and gave them brewed pine needle tea. Most recovered. Mr Cartier went back to France and told his superiors and would not listen. Of course it was scurvy caused by lack of C.
All of the members of our farm ministry learn about Klenner’s Vitamin C Baby protocol. To withhold this information from pregnant women is a crime against humanity that rivals quack-sin-ation.
https://open.substack.com/pub/theofarmer/p/vitamin-c-babies?r=1b6737&utm_medium=ios
Question
How is Vitamin C processed?
Interesting I have been trying this just aurally when I get cold symptoms and within 48-72 hours the symptoms have gone, I find you can tell when the vit c is starting to wear off and and a top up of 1-2000 mg soon sorts them out
You can add sepsis to the list. Dr Levy in his book explains when the vitamin C dose is high enough it triggers the Fenton Reaction which forces the intercellular H2O2 to release its single bond oxygen atom and thereby becoming an oxidant. Dr Paul Marik has used this to cure sepsis.
Thxs for highlighting Dr Klenner's work.
It was tge censorship of vitamin C in February 2020 that alerted me to something is up.
Here is the vit C timeline
https://totalityofevidence.com/vitamin-c
Is it scientifically correct to make the equation VitaminC=AscorbicAcid? And how is "vitamin C in powder form" produced, as I doubt it is from ground dried lemons...
I appreciate the article and apologies for being a curmudgeon (the role nature has conferred upon me).
Alternative Hypothesis: What if L-Ascorbic acid was preventing the body's natural elimination methods that we call "disease"?
If you prevent the body from eliminating toxins through the skin (preventing Measles) by administration of a concentrated extract like vit. C or Vit. A etc. then what happens to those poisons? For example, are they transported to the liver for elimination via bile or do they get rolled up into a tumour to be discovered later?
Daniel Roytas said that to prevent scurvy the whole fruits and plants were much more effective than this one extracted compound. We have ignored hundreds of other compounds in the citrus or other plants in order to promote a pill containing just a single compound.
The only magic pill that I have personally investigated that has any benefit is mineral water that is rich in silicon. This is for removal of aluminum and restoration of a sound mind (a friend with early Alzheimer's and a grandson with mild autism symptoms fully and partially recovered respectively).
Eat plants, sweat it out, get sun and rest.
Excellent!
What happens when Vitamin C cures a disease, any disease? The cure is simply ignored. If we check the medical references, MERCK, Langes, Harrisons, and Ferris - all suggest Vitamin C as a "treatment" for scurvy. The word "cure" is not used. In addition, there is no cure offered for Vitamin C deficiency. Vitamin C is not recognized as the cure for Vitamin C deficiency. Not only that, it cannot be approved as a cure - it does not qualify. In addition, CURED is simply not defined medically for Vitamin C deficiency, and CURED is not medically defined for scurvy. There is no medical test for Vitamin C deficiency cured. There is no medical test for scurvy cured.
It is not possible to prove than any case of disease has been cured by Vitamin C today.
We should not be surprised that Vitamin C is not recognized as a cure for many other diseases. It is simply not permitted to cure.
to your health, tracy
Author: A New Theory of Cure
Hello and thank you! Is there a resource for learning how to inject vitamin C at home?
No need
You can get ascorbic acid powder and take the same amount orally dissolved in water.
https://beyondhealth.com/blog/taking-vitamin-c-to-bowel-tolerance/
https://vitamincfoundation.org/www.orthomed.com/titrate.htm
You could look for a place near you that offers vitamin infusions. From the website of a center near me: ..In general, high dose vitamin C infusions are administered 2-3 times week. A G6PD blood test is required prior to starting the treatments.
Depending upon the situation they may be able to tailor the protocol so that an adequate amount of vitamin C is utilized.